Parthasarathy, A., Herikstad, R., Bong, J. H., Medina, F. S., Libedinsky, C.*, & Yen, S. C.* (2017). Mixed selectivity morphs population codes in prefrontal cortex. Nature Neuroscience, 1-10. (full text, suppl.)
*Equal Contribution
Highlighted in Nature Reviews Neuroscience (link)
Brief Summary: Monkeys were trained to perform a delay saccade task with interfering distractors. This task required the maintenance of spatial information despite distracting stimuli. We recorded from neurons in the LPFC and the FEF and found that the code used by LPFC, but not FEF, morphed to a different code after the distractor was presented. The morphing was assessed using cross-temporal decoding and state-space analysis: the code employed by LPFC to encode memory information during the first delay period (before the distractor) could not be used to predict the location of the memory during the second delay (after the distractor). We found that neurons with mixed selectivity, and primarily those with non-linear mixed selectivity, were necessary and sufficient for the code-morphing to occur. These neurons encoded both the target location and the task epoch (delay period before or after the distractor) in a non-linear manner (i.e. there was an interaction between both types of information). These results are hard to reconcile with the predominant view of a stable code during memory maintenance and raise the question of how downstream areas may be able to interpret this information in a stable manner. Furthermore, we highlight functional differences between the FEF and LPFC in memory maintenance and distractor suppression.

Tay, N., Tan, Y., Chng, K., Libedinsky, C., Gluckman, P., & Buschdorf, J. (2017). Effect of human milk formula with bovine colostrum supplementation on bone mineral density in infant cynomolgus macaques. Journal of Developmental Origins of Health and Disease, 1-10. doi:10.1017/S2040174417000812

Camilo Libedinsky*, Rosa So* , Zhiming Xu, Toe K. Kyar, Duncun Ho, Clement Lim, Louiza Chan, Yuanwei Chua, Lei Yao, Jia Hao Cheong, Jung Hyup Lee, Kulkarni Vinayak Vishal, Yongxin Guo, Zhi Ning Chen, Lay K. Lim, Peng Li, Lei Liu, Xiaodan Zou, Kai K. Ang, Yuan Gao, Wai Hoe Ng, Boon Siew Han, Keefe Chng, Cuntai Guan, Minkyu Je, Shih-Cheng Yen (2016) Independent Mobility Achieved through a Wireless Brain-Machine Interface. PLOS One 11(11): e0165773. doi:10.1371/journal. pone.0165773 (full text)
*Equal Contribution

Massar, S. A.*, Libedinsky, C.*, Weiyan, C., Huettel, S. A., & Chee, M. W. (2015). Separate and overlapping brain areas encode subjective value during delay and effort discounting. Neuroimage120, 104-113 (full text)
*Equal Contribution

Libedinsky, C., Massar, S. A., Ling, A., Chee, W., Huettel, S. A., & Chee, M. W. (2013). Sleep deprivation alters effort discounting but not delay discounting of monetary rewards. Sleep36(6), 899-904 (full text)

Lee, Y., Chong, M. F., Liu, J. C., Libedinsky, C., Gooley, J. J., Chen, S., … & Lee, Y. S. (2013). Dietary disinhibition modulates neural valuation of food in the fed and fasted states. The American journal of clinical nutrition97(5), 919-925 (full text)

Libedinsky, C., Smith, D. V., Teng, C. S., Namburi, P., Chen, V. W., Huettel, S. A., & Chee, M. W. (2011). Sleep deprivation alters valuation signals in the ventromedial prefrontal cortex. Frontiers in behavioral neuroscience(full text)

Libedinsky C, Livingstone M. (2011) Role of prefrontal cortex in conscious visual perception. Journal of Neuroscience 31(1):64-9 (full textsuppl)

Libedinsky C, Savage T, Livingstone M. (2009) Perceptual and physiological evidence for a role for early visual areas in motion-induced blindness. Journal of Vision 9(1):14.1-10 (full text)

Major, D. E., Rodman, H. R., Libedinsky, C., & Karten, H. J. (2003). Pattern of retinal projections in the California ground squirrel (Spermophilus beecheyi): anterograde tracing study using cholera toxin. Journal of Comparative Neurology463(3), 317-340 (full text)